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KMID : 0043319950180010008
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Archives of Pharmacal Research
1995 Volume.18 No. 1 p.8 ~ p.11
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Biodegradability of poly(r-benzyl L-glutamate)/poly(ethylene oxide)/poly(r-benzyl L-glutamate) Block Copolymer in Mice
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Oh In-Joon
Oh Jhin-Yee
Cho Chong-Su
Lee Kang-Choon
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Abstract
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Biodegradability of poly block copolymer (GEG) having different content of poly(ethylene oxide) (PEO) were examined using magnetite as a tracer in mice. GEG microspheres containing magnetite were injected into mice through tail vein. Biodegradability and tissue distribution of microspheres were examined by analyzing the amount of magnetite in the microspheres recollected from mice organs after specific time interval. The results showed that GEG microsphere of high content of PEO was degraded more rapidly than those of low content of PEO in the mice organs.
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KEYWORD
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Biodegradability, Magnetite, Microspheres$Poly(’[\gamma}-benzyl{\, }L-Glutamate)$, Poly(ethyl-lene oxide), Block copolymers
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